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ProPASS Publications

Vigorous Intermittent Lifestyle Physical Activity and Cancer Incidence Among Nonexercising Adults

This was a study by the core team of ProPASS collaborators. This study in JAMA Oncology examines the association between vigorous intermittent lifestyle physical activity (VILPA) and cancer incidence among 22,398 non-exercising adults from the UK Biobank, followed-up for about 7 years. The study found even small amounts of VILPA, accrued in bouts of up to 1 or 2 minutes during daily activities, were associated with a lower risk of incident cancer. Specifically, 4.5 minutes/day accrued in short bouts was associated with a 20% lower risk of total cancer and a 31% lower risk of physical activity-related cancer (composite of 13 cancer sites known to be related to physical activity levels, such as colon and lung cancer ). These findings suggest that even brief bouts of vigorous physical activity integrated into daily life may be a feasible and effective strategy for cancer prevention. This may provide promising intervention strategies particularly among individuals who are unable or unmotivated to exercise.

Device-measured physical activity and cardiometabolic health: the Prospective Physical Activity, Sitting, and Sleep (ProPASS) consortium

The University of Sydney’s Charles Perkins Centre Physical Activity, Sitting, and Sleep (ProPASS) Consortium and the Mackenzie Wearables Research Hub @ The Charles Perkins Centre provide a comprehensive study in the European Heart Journal delving into the interplay of physical activity, sleep, and sedentary behaviour from pooling data across 6 cohorts in 5 countries to assess cross-sectional associations with cardiometabolic markers such as high/low density lipoproteins, triglycerides, and body mass index. The study highlights every movement counts and underscores that reallocating time from sedentary behaviours to standing, light, or moderate-vigorous physical activities can have positive impacts on cardiometabolic health. Replacing 30 minutes/day of sitting with moderate-vigorous physical activity was associated with 0.63 (95% CI: 0.48, 0.79) kg/m2 lower body mass index. The findings emphasise finding the right balance of physical activity, sleep, and sedentary time.

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